99mTc-labeled aminosilane-coated iron oxide nanoparticles for molecular imaging of ανβ3-mediated tumor expression and feasibility for hyperthermia treatment


Dual-modality imaging agents, such as radiolabeled iron oxide nanoparticles (IO-NPs), are promising candidates for cancer diagnosis and therapy. We developed and evaluated aminosilane coated Fe3O4(10 ± 2 nm) as a tumor imaging agent in nuclear medicine through 3-aminopropyltriethoxysilane (APTES) functionalization. We evaluated this multimeric system of targeted 99mTc-labeled nanoparticles (NPs) conjugated with a new RGD derivate (cRGDfK-Orn3-CGG), characterized as NPs-RGD as a potential thermal therapy delivery vehicle.

Published in

Journal of Colloid and Interface Science

Authored by

Tsiapa, I.; Efthimiadou, E. K.; Fragogeorgi, E.; Loudos, G.; Varvarigou, A. D.; Bouziotis, P.; Kordas, G. C.; Mihailidis, D.; Nikiforidis, G. C.; Xanthopoulos, S.; Psimadas, D.; Paravatou-Petsotas, M.; Palamaris, L.; Hazle, J. D.; Kagadis, G. C.

Publication date

Saturday, November 1, 2014
Resource category
Technique category